Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths
Figure 7
Global sensitivity for kinetic paths.
The developmental and reprogramming paths comparisons before and after mutations are shown separately for mutation 1 (increase link R1, i.e. the repression of CDX2 to OCT4)(A), mutation 2(increase link R2, i.e. the repression of OCT4 to GATA6)(B), mutation 3 (increase link R3, i.e. the repression of NANOG to GATA6)(C), and mutation 4 (increase link R4, i.e. the repression of GATA4 to GATA6)(D). The blue paths represent kinetic paths before mutations, and the magenta paths represent the kinetic paths after mutations. The blue arrows represent differentiation direction (from left stem cell attractor to the right differentiation attractor), and the magenta arrows represent reprogramming direction (from right attractor to left attractor). The diffusion coefficient .