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Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths
Figure 6
Results of the global sensitivity analysis in terms of barrier height and MFPT (mean first passage time) when parameters are changed.
The results in (A) are for 6 repression links (named respectively as R1,R2,…,R6, see Table S2) based on the change of barrier heights (
). The results in (B) are for 14 activation links (named respectively as A1,A2,…,R14, see Table S3) based on barrier heights. Blue bars represent the change of 
(barrier for differentiation process), red color represent the change of 
(barrier for reprogramming process). (C) and (D) separately show the corresponding results in terms of the change of MFPT (
). Blue bars represent the MFPT change for differentiation process, and red bars represent the MFPT change for reprogramming process. (E) shows the corresponding global sensitivity for the knockdown of individual genes.
doi: https://doi.org/10.1371/journal.pcbi.1003165.g006