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Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths
Figure 4
The barrier height and MFPT (mean first passage time) results when the activation strength 
, the repression strength 
as well as the noise level 
changes (Langevin dynamics).
(A)(B) show that when 
increases, stem cell state becomes more stable, the barrier for stem cell state 
(or the barrier for differentiation process 
) increases, and the MFPT for differentiation process from stem cell state to differentiation state (
) increases. By contrast, When 
increases, differentiation state becomes less stable, the barrier for differentiation state 
(or the barrier for reprogramming process 
) decreases, and the MFPT for reprogramming process from differentiation state to stem cell state (
) declines. (C)(D) show that when 
increases, the barrier for stem cell state 
(
), the barrier for differentiation state 
(
), the MFPT for differentiation process (
), and the MFPT for reprogramming process (
) all increase. (E)(F) show that when noise level 
increases, the barrier for stem cell state 
(
), the barrier for differentiation state 
(
), the MFPT for differentiation process (
), and the MFPT for reprogramming process (
) all decrease.
doi: https://doi.org/10.1371/journal.pcbi.1003165.g004