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Quantifying Cell Fate Decisions for Differentiation and Reprogramming of a Human Stem Cell Network: Landscape and Biological Paths

Figure 2

A bistable landscape picture for the stem cell network.

Parameters are specified as: (degradation), (repression), (activation), and diffusion coefficient . (A) Three dimensional landscape and dominant kinetic paths. The yellow line represents developmental path, and the magenta line represents reprogramming path. (B) Two dimensional dominant kinetic path and flux on the landscape. The white arrows represent the direction of flux, and the red arrow represent the direction of the negative gradient of potential energy.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1003165.g002