Variations within Class-A β-Lactamase Physiochemical Properties Reflect Evolutionary and Environmental Patterns, but not Antibiotic Specificity
Figure 3
Relationship between phylogeny and electrostatic potential maps.
The class-A β-lactamase family phylogeny is shown, which differentiates into 7 subgroups using a constant cut-level. Outgroups are represented by a unique color for better visualization. The structures closest to the phylogeny are oriented to highlight the active site region, which is indicated in green in the TEM-1 ortholog. Structures in the outer ring have been rotated in the y-direction by approximately 90 degrees, which highlights the Ω-loop region, also indicated in green. It is clear that structures from the same outgroup have visually similar electrostatic potential maps, whereas there are significant differences across the whole phylogeny.