Dynamics of SIN Asymmetry Establishment
Figure 3
Model expansion on Cdc11 regulation.
The minimal model was extended by multiple phosphorylation forms of Cdc11 (A). It can be phosphorylated by SIN (green), Cdk (light blue) and both. The Cdk sites are assumed to be dephosphorylated by the unknown phosphatase “ppC”, while the SIN sites are dephosphorylated by an unknown phosphatase, “ppS”. (B) Simulation time course of SIN and Byr4 activities at the two SPBs (solid for Old, dashed for New). (C) Changes in the various phosphorylated forms of Cdc11. Notations and color code on forms on panel A.