Dynamics of SIN Asymmetry Establishment
Figure 1
A minimal model for SIN asymmetry establishment.
(A) Direct antagonistic interactions between molecule X and Y at the two SPBs. Both molecules induce the removal of the other from the SPB they are both bound. Solid lines are transitions, dashed arrows show catalytic effects. (B) A less than 0.1% difference in the SPB binding rates or in initial conditions (not shown) can induce quick asymmetry establishment. Solid lines for molecules at old SPB, dashed lines for molecules at new SPB, time is in arbitrary units. (C) The proposed antagonistic double-negative ( = positive) feedback between SIN components and Cdc16-Byr4. (D) Merging ideas from panels A and C to create a minimal molecular model of asymmetry establishment.