Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein
Figure 4
GNM cross-correlations of apo/holo CRP and the switch behavior.
Comparison of the correlations between residue fluctuations in average ten slowest modes for the apo CRP NMR solution structure (PDB: 2WC2, model 1) and holo CRP X-ray crystal structure with the two cAMPs bound (PDB: 1G6N). Below, the ribbon diagrams color coded with the correlation values of the L134-D138 hinge (average) with the rest of the structure are given. The difference-correlation map of the two correlation maps is given in the middle.