Transcription Factor Binding Profiles Reveal Cyclic Expression of Human Protein-coding Genes and Non-coding RNAs
Figure 4
Tissue specificity of cell cycle predictive models.
(A) The ROC curves when TF binding data from different cell lines are used as predictors in the combined model. (B) Similar to (A), but results are from TF-only model. (C) The regulatory scores of E2F4 on Hela cell cycle genes in HelaS3 versus K562 cells. Note that a small subset of genes shows strong E2F4 binding only in Hela cells. (D) E2F4 regulates overlapping but different target genes in HelaS3 versus K562. (C) and (D) are based on ENCODE ChIP-seq data.