Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling Approach
Figure 9
Possible dynamics of HBV cccDNA between vector delivery doses.
(a) Cell death inducing decay of incorporated episome. (b) Episomal degradation. (c) cccDNA expansion despite suppressive antiviral therapy. (d) Hepatocyte replication with equal dispersion of cccDNA molecules between cells. (e) Hepatocyte replication with replication of cccDNA molecules between cells. Only mechanism (c) could increase number of doses needed prior to inactivation while other mechanisms (a, b and d) may allow more rapid cure.