Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling Approach

Figure 5

A single cell may contain episomes with different degrees of resistance to multiple enzymes.

Example of one theoretical cell containing 6, 3, 2 and 1 episomes with 0, 1, 2, and 3 mutations respectively, as well as 3 delivery vectors.