Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling Approach
Figure 3
Possible outcomes for a single episome with three possible cleavage sites.
Any cleavage event that renders the molecule replication incompetent is a terminal event for the episome; induced resistance at one site still leaves other potential target sites susceptible to cleavage. Arrow thickness denotes the relative probability of a certain event.