Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling Approach
Figure 1
Schematic of gene therapy vector delivery.
(a) There is a probability, Pv = [(σ*m)v * e−(σ*m)]/v!, of different amounts of vector (red) being delivered to and transduced within each cell containing the target virus (green). (b & c) The percentage of cells with different amounts of transduction will vary according to functional multiplicity of infection (fMOI) which is equal to the ratio of transduced delivery vectors to target hepatocytes multiplied by the proportion of vectors which are transduced, or fMOI = m * σ.