Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways
Figure 7
Performance of the PathSiMMap compared with site-moiety map-based and energy-based methods for (A) SDH and (B) SK.
The PathSiMMap (blue line) is the best and significantly outperforms the site-moiety map (red line) and the energy-based method (green line) for identifying SDH and SK inhibitors.