Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways
Figure 6
Specific anchors and selective inhibitors of shikimate dehydrogenase (SDH).
(A) Specific anchors of SDH. The specific site includes these anchors H3, V1, and V3. (B) Compound structures and IC50 values of two selective inhibitors. Docking poses of these two selective inhibitors (C) NRB03174 and (D) HTS02873.