Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways
Figure 5
Comparison of conservation scores.
(A) Conservation-score distribution of pathway anchor residues, anchor residues, binding site residues, and other residues. The scores are from 1 (least conserved) to 9 (most conserved). (B) Conservation-score distribution of pathway anchors and anchors. A conservation score of a pathway anchor or an anchor is derived by averaging the conservation scores of pathway anchor residues or anchor residues.