Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways
Figure 4
New multitarget inhibitors identified by the pathway-based screening strategy.
(A) The compound structures and IC50 values of the multitarget inhibitors. The relationships between the inhibitors and the pathway anchors are represented by green (hydrogen-bonding interactions) and gray (van der Waals interactions) circles. Docking poses of these inhibitors and anchor residues of (B–D) SDH and (E–G) SK.