Pathway-based Screening Strategy for Multitarget Inhibitors of Diverse Proteins in Metabolic Pathways
Figure 2
Pathway site-moiety map of SDH (yellow) and SK (purple).
(A) Superimposed binding sites of SDH and SK by the anchor-based alignment method. Four pathway anchors were identified despite low sequence and structure similarities of SDH and SK. Hydrogen-bonding and van der Waals anchors are colored in green and gray, respectively. (B) Common moiety preferences of four pathway anchors.