Reconstruction and Validation of a Genome-Scale Metabolic Model for the Filamentous Fungus Neurospora crassa Using FARM
Figure 9
Synthetic lethality interaction map.
This gene-by-gene interaction map shows synthetic lethal predictions on Vogel's minimal media, except the double mutant pyr-1:uc-5 is on Vogel's+uracil. Shown are non-isozyme pairs, except the previously known isozyme pair cys-13:cys-14. If both synthetic lethal genes of a pair are in a common pathway, the square is cyan; if they are in interacting pathways, then it is colored orange. Validated synthetic lethal predictions have a black border.