A Design Principle of Group-level Decision Making in Cell Populations
Figure 5
Conditions for collective decision making in dynamical quorum sensing.
(A–B) CVρ/CVk (see Models) in the absence (A, |ηi| = 0) or the presence (B, |ηi| = 0.1) of noise in a positive-and-negative feedback circuit (Eq. 4). NT: No Transition, i.e., constitutive quiescence or constitutive oscillations irrespective of cell density (white region). The × and + correspond to Figs. 4A and 4B, respectively. (C) Log10 CVρ/CVk = 0 in the absence (green curve) and the presence (yellow curve) of noise. The black solid line indicates the boundary ε∼2 (Eq. S2-27 in Text S1). The region surrounded by the black dotted curves marks the parameter region where the cells are autonomously oscillatory in an isolated condition (ρ = 0). The values of the parameters are the same as those in Fig. 4.