A Design Principle of Group-level Decision Making in Cell Populations
Figure 4
Graded and all-or-none transitions to collective oscillations.
(A–B) Representative time courses of oscillatory transitions within populations of positive-and-negative feedback circuits (Fig. 1E; Eq. 4) for high ε (ε = 16; A,C) and low ε (ε = 4; B,D). λ = 103, g = 30, and |ηi| = 0. Upper panels: time course of the population mean (red line) and the synthetase concentration of a representative cell (blue line) during an exponential increase in cell density ρ (grey line). Lower panels: pulsatile responses of individual cells. Y-axis indicates the cell index. (C–D) Percentage of oscillatory cells plotted as a function of cell density.