Optimal Dynamics for Quality Control in Spatially Distributed Mitochondrial Networks
Figure 8
Maximal autophagy and replication rates affect health and mitochondrial population size in distinct manners.
(A) Restricting the maximal autophagy rate causes a decrease in steady-state health with relatively little effect on population size, indicating that autophagy is critical to maintaining a healthy population. (B) In contrast, cells maintain high average health when the maximal replication rate is restricted, while the population size decreases. All damage rates are in units of .