Optimal Dynamics for Quality Control in Spatially Distributed Mitochondrial Networks
Figure 7
Motion dependence of fusion alters health by rescaling the effective fusion rate.
(A) Rates of fusion were scaled down by or
if only one or neither, respectively, of the fusing mitochondria were actively being transported at the time of fusion. Transport occurs at velocity
. (B,C) Decreasing
(B) or
(C) for fixed
leads to a decrease in health. In (B),
; in (C),
. (D) Over a wide range of values of
and
, the frequency of fusion events was highly related to average health. The colors correspond to the same fusion rates specified in (B). All fusion rates are in units of
.