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Optimal Dynamics for Quality Control in Spatially Distributed Mitochondrial Networks
Figure 6
Health is insensitive to density as long as fusion events are sufficiently frequent.
(A) In simulations within cells of different sizes, average steady-state health plateaus after a filling fraction of 
. (B) Typical network architectures at the points labeled in (A). Each mitochondrion has a radius of 
in all simulations and is colored according to its health. Mitochondria above and below 
and 
appear in shades of green and red, respectively. (C) Histograms of the number of mitochondria in networks of different sizes. The solid lines correspond to the networks formed only by fused neighbors, while the dashed lines correspond to networks of touching mitochondria regardless of fusion state. (D) The frequency of fusion events as a function of density, showing the same transition at 
filling fraction.
doi: https://doi.org/10.1371/journal.pcbi.1003108.g006