< Back to Article

Optimal Dynamics for Quality Control in Spatially Distributed Mitochondrial Networks

Figure 5

Mitochondrial health is maximized when the thresholds for autophagy () and fusion () are equal.

(A) For each , the average health (values represented by the color bar) is maximized when has the same value (blue circles), suggesting that the mechanism for fusion selectivity shares molecular components with autophagy selectivity. (B) Distributions of health across the mitochondrial population once simulations reach a steady state for different values of and , highlighting the effects of unequal thresholds (ii and iii). Gray regions indicate the mitochondria that can undergo autophagy, while red regions indicate the mitochondria that can undergo fusion.

doi: https://doi.org/10.1371/journal.pcbi.1003108.g005