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Optimal Dynamics for Quality Control in Spatially Distributed Mitochondrial Networks

Figure 4

Maximal average steady-state health occurs for maximal asymmetry generation through stochastic exchange and fission.

In each simulation, each mitochondrion has health units, and thus exchanging units is equivalent to exchanging units. For all fusion rates, the average steady-state health is maximized when 5 units (or half the total number) are exchanged during each fusion and fission event. Health reaches a plateau for all values of exchanged HUs at fusion rates of . All fusion rates are in units of .

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1003108.g004