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Gag-Pol Processing during HIV-1 Virion Maturation: A Systems Biology Approach

Figure 8

The rate of change in the concentration of a given fragment S_i,j.

Assuming quasi steady state for the enzyme-substrate complexes, , the rate of change consists of loss by cleavage at any of the internal cleavage sites, and production by “trimming” longer fragments that have an uncleaved site at either terminus.

doi: https://doi.org/10.1371/journal.pcbi.1003103.g008