Gag-Pol Processing during HIV-1 Virion Maturation: A Systems Biology Approach
Figure 6
Accuracy of predicting combined parameter effects on VMT assuming additive (A) and multiplicative (B) interaction.
Simulations were run with a geometric series of 20 values ranging from 0.16 to 6.25 times the default for both parameters, and with all 400 combinations of the variants. Under the additive model, predictions of combined effects were obtained by adding up absolute changes in VMT observed when changing each of the parameters separately; predictions under the multiplicative model were obtained by multiplying the relative (fold change) individual effects. Deviations (in minutes) from both predictions are plotted with color-coding; the dimensions of both parameters were s−1. The additive model performs better (smaller deviation) when both parameters are increased or both are decreased; the multiplicative model performs better when one parameter is increased and the other decreased.