Gag-Pol Processing during HIV-1 Virion Maturation: A Systems Biology Approach
Figure 5
Isoclines of virion maturation time (VMT).
The isoclines are drawn in the plane of the two rate parameters with the strongest effect on VMT. Generic hyperbola-like functions of the form y = a+b/(x−c)d could be fitted to the data. For VMT = 15 min: a = 10−4, b = 5×10−4, c = 0.058, d = 0.69; for VMT = 30 min: a = 10−4, b = 10−4, c = 0.027, d = 0.79; for VMT = 45 min: a = 9×10−5, b = 2×10−5, c = 0.017, d = 0.93; dimensions for parameters a–c and for both axes of the figure are s−1. The perpendicular lines indicate the default values of both parameters.