Gag-Pol Processing during HIV-1 Virion Maturation: A Systems Biology Approach
Figure 3
The processing of canonical cleavage sites in the simulations of Gag and Gag-Pol processing.
(A) The fraction of a given cleavage site that is yet uncleaved (the total concentration of all molecular species that contain the uncleaved site, divided by the initial concentration of Gag or Gag-Pol, respectively). (B) The order of cleavage defined by the time points when a fixed threshold of processing (50% and 95%), indicated by horizontal lines, has been reached. (C) Schematic representation of the proposed order of processing events in HIV-1 Gag and Gag-Pol, respectively. The size of the arrowheads indicates different rates of cleavage, with large arrowheads representing faster cleavage. The order of processing for Gag is based on the times needed to attain 50% processing in the model, as in (B). Note that the sizes of arrowheads are not drawn to scale.