The Ability of Flux Balance Analysis to Predict Evolution of Central Metabolism Scales with the Initial Distance to the Optimum
Figure 4
Measures of optimality and predictability after adaptation to lactate for ∼900 generations.
A,D) The % optimality of the ancestor (black) and evolved isolates (grey); B,E) distance to optimal flux distribution (plotted as log(DEO/DAO)); and C, F) comparison of predicted to observed flux ratios for FBA-predictions based upon BM/S (A–C) or ATP/S (D–F).