Human Germline Antibody Gene Segments Encode Polyspecific Antibodies
Figure 5
Interface occurrences affect germline sequence recovery.
For VH3-23 (A) and VH1-69 complexes (B), we binned each residue position into how many times it occurred in an interface (interface ensembles). Most designed positions never occurred in an interface. As their occurrences became more frequent, we observed a trend for increasing the recovered germline residue. This trend fell off for VH1-69 complexes (B) for positional occurrences between 5–8 interfaces.