A Balance Equation Determines a Switch in Neuronal Excitability
Figure 7
Modifications in the balance between restorative and regenerative channels induce excitability switches in conductance-based models.
The figure sketches excitability switches of the Hodgkin-Huxley (HH) model [2], Aplysia's R15 neuron (R15) model [6], a dopaminergic (DA) neuron model [3], thalamic reticular (RT) and relay (RE) neuron models [4], [5], and a cerebral granule cell (GC) model [7] on the excitability parameter map computed for the two-dimensional model of [1]. All these conductance-based models can switch between restorative and regenerative excitability through the physiologically relevant regulation of specific ion channels.