Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity
Figure 4
Peroxisome proliferator activated receptor gamma (PPARγ) ameliorates colonic inflammation and clinical signs of disease.
(A) SCID recipients were administered either wild-type or PPARγ null naïve CD4+ T cells. Representative photomicrographs of colons from (A.A–A.D) non-transferred (A.B–A.E) wild-type recipient and (A.C,A.F) T cell-specific PPARγ null recipient mice. Original magnification 40 or 100×. (B) Disease activity scores of SCID recipient mice of wild-type or PPARγ null naïve CD4+ T cells. Data are represented as mean ± standard error. Points with an asterisk are significantly different when compared to the PBS-treated group (P<0.05).