Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure
Figure 7
JAK2 JH1-JH2 complex model involves two sets of significant interfacial residues.
The JH2 (residues 523 to 816) is shown in blue cartoon while the kinase domain (residues 840 to 1132) is shown in yellow cartoon. The linker loop between two domains is colored pink. Interface 1 shows a site of electrostatic complementarity near the αC helix region of the JH2 and the αEF/αF loop region of kinase domain. The electrostatic complementarity is provided by R588, E592, E1028 and K1030. Interface 2 is composed of mainly hydrophobic residues, especially V706, L707, I901, R971, I973 and V1033.