Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure
Figure 4
Correlated motions couple active to putative allosteric sites in the JAK2 JH1 and JH2 domains.
(A) The pairwise matrix of the highly coupled residues in the inactive conformation of the JAK2 JH1 domain. (B) Strong correlations between the activation loop (green box) and the αC helix (red box) are observed in the JH1 domain (yellow in cartoon). (C) The pairwise matrix of the highly coupled residues in the active conformation of the JH2 domain. (D) The strong correlations of the loop between β7–β8 sheets near the hinge region (green box) with activation loop (red box) shown in the JH2 domain (blue in cartoon).