Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure
Figure 3
Starting models were generated by connecting sites identified by MutInf or by using dimer geometries from crystal structures.
(A) Two predefined packing models were constructed by manually joining the αC helix in the JAK2 kinase domain with two highly coupled sites in the JH2 pseudokinase domain identified by MutInf. (B) Four additional packing models were built by alignment to crystal structures of kinase dimeric forms (FGFR1, FGFR2, BRAF and PKB).