Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

doi:10.1371/journal.pcbi.1003016

Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps

Figure 4

Pathway steady states for various combinations of parameters in the mathematical model of DNA repair with reversible steps and a toxic intermediate.

The classification of pathway steady states depends on the values of three control parameters, representing the ratios of some kinetic rates of the model (for more details see Section S2A in Text S1): The diagrams visualize the values of the control parameters where thickness of the solid arrows shows the relative value of the corresponding kinetic rate and the dashed arrows represent kinetic rates which values are irrelevant for a given scenario. Color coding shows partial orderings of the parameters important for a given pathway state (thickness of edges of the same color should be compared but not between color.

doi: https://doi.org/10.1371/journal.pcbi.1003016.g004