Origin and Evolution of Protein Fold Designs Inferred from Phylogenomic Analysis of CATH Domain Structures in Proteomes
Figure 10
Cumulative frequency distributions of Ts and Hs belonging to a particular A along timeline of domain structures.
Plots A and B describe the evolutionary appearance of T and H domain structures, respectively. These two plots uncover patterns of diversification of structural designs in architectures over time. For example, the evolutionary accumulation of Ts and Hs belonging to the oldest architecture, the 3-layer (αβα) sandwich (3.40), occurs early but at different rates than Ts and Hs belonging to the orthogonal bundle (1.10) and 2-layer sandwich (3.30). The same pattern can be seen in (B), where the accumulation of the 4-layer sandwich (1.20) surpasses that of the α-β complex (3.90), even if 3.90 is more older than 1.20.