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Origin and Evolution of Protein Fold Designs Inferred from Phylogenomic Analysis of CATH Domain Structures in Proteomes

Figure 7

A phylogenomic tree of proteomes generated from the equally sampled dataset of FL proteomes.

The circular cladogram of the most parsimonious rooted tree describes the evolution of 123 equally sampled proteomes and was generated from genomic abundances of 2221 Hs. Terminal nodes of Archaea (A: 41 proteomes), Bacteria (B: 41), and Eukarya (E: 41) were labeled in red, blue, and green, respectively. Also the total character set was divided into three independent character sets e.g. Most Ancient (ndH 0∼0.176), Ancient (ndH 0.176∼0.318) and Younger (ndH 0.318∼1) characters set. These character sets resulted in three trees of proteomes that reflected the behavior of the tree over different character sets. Root branches are indicated with arrows.

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.1003009.g007