Origin and Evolution of Protein Fold Designs Inferred from Phylogenomic Analysis of CATH Domain Structures in Proteomes
Figure 5
Architectural chronologies of CATH A, T and H domain structures.
Three phases or epochs (I, II and III) in the timeline delimit the appearance, crystallization and diversification of As (A), Ts (B) and Hs (C) in all three superkingdoms (top panels) and in Archaea, Bacteria, and Eukarya (bottom panels). Individual plots show the relationship of f (distribution Index) and age of domain structures defined at A (ndA), T (ndT) and H (ndH) levels of structural abstraction.