Origin and Evolution of Protein Fold Designs Inferred from Phylogenomic Analysis of CATH Domain Structures in Proteomes
Figure 3
Phylogenomic tree of CATH A domain structures.
Optimal (P<0.01) most parsimonious A (26,323 steps; CI = 0.3738, RI = 0.7655; g1 = −0.427) tree was reconstructed from a protein domain census in 492 completely sequenced genomes. The phylogeny was plotted into circular tree diagram and cartoon representations of the core structures labeled with each CATH id were mapped onto the leaves of the tree. The Venn diagram shows the diversity of A in the three superkingdoms, Archaea, Bacteria and Eukarya.