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Lifespan Differences in Hematopoietic Stem Cells are Due to Imperfect Repair and Unstable Mean-Reversion

Figure 7

Failure Rate Phase Space Regimes of Long-term Repopulating HSCs.

Phase space plot of the failure rate kinetic of a long-term repopulating HSC with long lifespan of months. Points in the plot (red) represent successive failure rates calculated every 2 months. To facilitate visualization, regions were separated by dotted lines. After initial expansion (region E, circled point), the kinetic transitions (blue arrow) into a regime (region OU), where it remains for most of clonal life. The behavior in region is governed by an Ornstein-Uhlenbeck iterative process (compare eq 4). The end of clonal life is indicated by the transition (black arrow) from region to the “terminal” absorbing point in region (circled point). Region B is not visited by the dynamic trajectory and, therefore, empty.

doi: https://doi.org/10.1371/journal.pcbi.1003006.g007