Lifespan Differences in Hematopoietic Stem Cells are Due to Imperfect Repair and Unstable Mean-Reversion
Figure 4
Failure Rate Kinetics of Long-term Repopulating HSCs.
To facilitate visualization, failure rate kinetics (vertical axes: each colored line-scatter curve represents the failure rates of the total output of an individual HSC) were displayed in three non-classifying groups (rows A–B, C–D, E–F) and at two levels of resolution (full kinetics in column A, C, E; -truncated kinetics in column B, D, F) over time (horizontal axes). The full kinetics show that the failure rates increase strongly as the lifespan is approached. We called this behavior the “extinction transition”. The
-truncated kinetics illustrate the variability, and a tendency to slowly increase, of the failure rates prior to reaching the extinction transition.