Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity
Figure 4
The absolute ZAP-70 affinity for -chain ITAMs modulates potency.
A) The concentration of bound ZAP-70 as a function of the concentration of active kinase (E) to phosphatase (F). Results are shown for the wild-type -chain (
123) and for three additional
-chains that contain all high affinity ITAM 1 (
111), intermediate affinity ITAM 2 (
222), or low affinity ITAM 3 (
333). Comparison of these
-chains reveals that B) sensitivity is unchanged whilst C) potency is modulated.