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Systems Model of T Cell Receptor Proximal Signaling Reveals Emergent Ultrasensitivity

Figure 3

ZAP-70 binding to phosphorylated ITAMs enhances both ultrasensitivity and potency.

A) The concentration of total -chain phosphorylation as a function of the relative concentration of active kinase (E) to phosphatase (F). Results are shown for sequential phosphorylation (blue, green) and random phosphorylation (red, orange) in the absence (blue, red) and presence (green, orange) of ZAP-70. B) Hill numbers and C) for all four curves reveal that ZAP-70 binding dramatically increases both ultrasensitivity and potency when phosphorylation is sequential but not random.

doi: https://doi.org/10.1371/journal.pcbi.1003004.g003