Systematic Prediction of Pharmacodynamic Drug-Drug Interactions through Protein-Protein-Interaction Network
Figure 4
(A) Desipramine and trimipramine. (B) Zonisamide and memantine. The drug target-centered systems (ellipse) colored for different drugs, includes drug targets (vee) and their first-step neighboring proteins (circle) in the PPI network. The edges in the network were weighted by the PCC based on cross-tissue expressions.