Systematic Prediction of Pharmacodynamic Drug-Drug Interactions through Protein-Protein-Interaction Network
Figure 3
(A) All possible drug pairs ranked and binned into groups by their S-score. (B) Fold-enrichment of hits of known PD-like DDIs in each bin (y-axis) plotted against average S-score (x-axis). (C) ROC curves to evaluate the performance of various scoring methods using DrugBank PD-like DDIs as GSPs. (D) ROC curves to evaluate the prediction performance of S-score using three types (PD, PK, pharmaceutical) or known DDIs in DrugBank as GSPs. (E) Associations of S-score with drug clinical side effect similarity (P-score). Average of P-score (y-axis) is plotted for top N% of drug pairs ranked by S-score (x-axis). P-value for top 5% drug pairs against all possible drug pairs was calculated from Wilcoxon rank sum test.