Systematic Prediction of Pharmacodynamic Drug-Drug Interactions through Protein-Protein-Interaction Network
Figure 1
PD DDIs reflected at the molecular network level.
(A) A representative example of drug target distance: the minimum distance of the shortest path between two drugs' targets on PPI network. (B–C) Hit rate (B) and coverage(C) of known PD DDIs among the drug pairs grouped by their target distances on the PPI network.