Under-Dominance Constrains the Evolution of Negative Autoregulation in Diploids
Figure 4
Evolution of autoregulatory binding sites.
Distribution of binding site strength achieved in evolutionary simulations for haploids (gray) and diploids (white). Hapoids are able to evolve stronger binding than diploids. The histograms shows results of replicate simulations for each ploidy level. The simulation procedure is described in the main text and the Materials and Methods. The optimal binding strength used was
, corresponding to a a background transcription rate
.